I would go for (ATX form factor in mind):
- Input OVP up to 500VAC (consisting of a small circuit with a normally-closed relay in one side of the mains input to the PSU circuitry that activates the relay if the voltage goes out of range, preventing damage to downstream circuitry)
- CAPZero
- Thermistor shorting relay (already a feature of high-end units)
- HiperPFS-2 (in a small unit - for larger units, a suitable discrete APFC solution)
- HiperLCS (small to medium units) or otherwise a suitable discrete LLC resonant solution for the main supply
- TinySwitch-4 for the standby supply
- Synchronous rectification (of course)
- The highest quality capacitors available e.g. Panasonic ED, EE or XB on the primary and FR on the secondary, and where suitable, solid polys or even ceramic capacitors
- Buck converters for +3.3V and +5V, and buck-boost for -12V. Cross-loading issues - gone.
- Protection against just about everything that can go wrong: Outputs shorted to ground or together (you may want a rather robust protection diode for -12V), excess current draw from any of the outputs (-12V included), overheating, fan failure, excessive ripple (I'm sure you've been waiting for that protection), you name it.
- Continual fan operation at low speed in standby mode to improve reliability. (Why don't more PSUs do this???)
- As for the fan itself, an 80mm fluid-dynamic bearing (or failing that, dual ball bearing) model, rear-mounted with a 20mm gap in front to minimise noise. The heatsinks are as large as desired and the front vent is a honeycomb type, covering the entire panel (excluding any space used by modular connectors).
- Two bi-colour LEDs on the rear panel for diagnostic purposes - see below for coding.
Green - operating
Orange - standby mode
Off - wait for power good
LED 2 ("protection"):
Green - normal
Orange - SCP, OCP, OPP, OVP, UVP tripped
Orange flashing - overheated, wait to cool down
Red - capacitor or fan failure
(Orange is obtained by mixing red and green.)
Note that gold plated connectors are not on the list. This is because gold and tin don't mix. Well, at least mixing them doesn't improve reliability over tin/tin. Only connectors that are gold plated as standard should be.
Also notably absent is the usual large fan. There are three reasons for this.